The process of innovation and entrepreneurship is complex and changeable, resulting in differences in innovation and entrepreneurship education from the teaching of general knowledge and technology, which needs the coordination in educational resources of all parties and the adoption of different educational methods according to different stages of innovation and entrepreneurship. Through constant exploration and breakthroughs in innovation and entrepreneurship education, starting with the supply-side reform of education, and combining with the life cycle theory, Wenzhou Polytechnic has carried out studies on the hierarchical education of innovation and entrepreneurship, dividing the innovation and entrepreneurship education in higher vocational colleges into four-levelsystematic education from the basic level, integrated professional level, practical level, to successful operation and exit level, so as to explore a new path for improving the quality and efficiency of innovation and entrepreneurship education in higher vocational colleges.