Based on the AI technology of support vector machine, the paper has established a mathematical prediction model, and made a big data analysis of college students’ entrepreneurship. The results have shown that reasonable curriculum and the integration of entrepreneurship and professional courses have a significant influence on students’ entrepreneurial intention; entrepreneurial practice, environment and intention are positively correlated; personal characteristics, including family background, psychological evaluation, work experience, etc., can affect the development of entrepreneurial behavior. To further enhance college students’ entrepreneurial intention and accurately carry out the innovation and entrepreneurship education, it is advisable to establish the educational concept of hierarchical classificationin personnel training, deeply integrate entrepreneurial education with professional education, promote the construction of platforms of phased educational practice, and establish an evaluation system combining processes with results.