In order to cultivate high-quality innovative technical and skilled talents with the spirit of Wenzhou people in the electrical industry,a CDIO-EF based professional courses teaching mode about integration of professional education and innovation and entrepreneurship education was proposed. The teaching mode was guided by industrial demand, threaded with product life cycle, carried by enterprise operation, and carried out project-based teaching of simulating the actual situation of enterprises, realized the integration and synchronization of industry and education. The teaching mode expanded entrepreneurship and innovation education on the basis of professional education, and regurgitation feeded entrepreneurship and innovation education for professional education. It proves that, the CDIO-EF based teaching mode about integration of professional education and innovation and entrepreneurship education, can effectively improve students" professional ability and entrepreneurship and innovation ability, and improve students" employment competitiveness and workplace adaptability.